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14-3-3 protein

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== Structural highlights ==
== Structural highlights ==
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==3D structures of 14-3-3 proteins==
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==3D structures of 14-3-3 proteins (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*14-3-3 protein σ
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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** [[1yz5]] – hPRS – human<br />
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===14-3-3 protein σ===
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*14-3-3 protein σ binary complex with peptide
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[[1yz5]] – hPRS – human<br />
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**[[1ywt]] – hPRS + phosphopeptide <br />
 +
**[[3lw1]] – hPRS + p53 peptide <br />
 +
**[[3iqj]], [[3iqu]], [[4iea]] – hPRS + Raf-1 peptide <br />
 +
**[[3mhr]] – hPRS + YAP peptide <br />
 +
**[[3p1n]] – hPRS + TASK-3 peptide <br />
 +
**[[3p1p]], [[3p1r]] – hPRS (mutant) + TASK-3 peptide <br />
 +
**[[4dat]], [[4dau]] – hPRS + PADI6 peptide <br />
 +
**[[4jc3]], [[4jdd]] – hPRS + estrogen receptor peptide <br />
 +
**[[4fl5]] – hPRS + τ protein peptide <br />
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''14-3-3 protein σ binary complex with peptide''
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*14-3-3 protein σ binary complex with small molecule
-
[[1ywt]] – hPRS + phosphopeptide <br />
+
**[[3u9x]] – hPRS + pyridoxal phosphate<br />
-
[[3lw1]] – hPRS + p53 peptide <br />
+
**[[3t0l]], [[3t0m]], [[4dhm]], [[4dhn]], [[4dho]], [[4dhp]], [[4dhq]], [[4dhr]], [[4dhs]], [[4dht]], [[4dhu]] – hPRS + inhibitor<br />
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[[3iqj]], [[3iqu]], [[4iea]] – hPRS + Raf-1 peptide <br />
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**[[4hqw]], [[4hru]] – hPRS + molecular tweezers<br />
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[[3mhr]] – hPRS + YAP peptide <br />
+
-
[[3p1n]] – hPRS + TASK-3 peptide <br />
+
-
[[3p1p]], [[3p1r]] – hPRS (mutant) + TASK-3 peptide <br />
+
-
[[4dat]], [[4dau]] – hPRS + PADI6 peptide <br />
+
-
[[4jc3]], [[4jdd]] – hPRS + estrogen receptor peptide <br />
+
-
[[4fl5]] – hPRS + τ protein peptide <br />
+
-
''14-3-3 protein σ binary complex with small molecule''
+
*14-3-3 protein σ ternary complex with stabilizer*
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[[3u9x]] – hPRS + pyridoxal phosphate<br />
+
**[[3p1o]], [[3ux0]], [[4fr3]] – hPRS + TASK-3 peptide + stabilizer<br />
-
[[3t0l]], [[3t0m]], [[4dhm]], [[4dhn]], [[4dho]], [[4dhp]], [[4dhq]], [[4dhr]], [[4dhs]], [[4dht]], [[4dhu]] – hPRS + inhibitor<br />
+
**[[3p1q]], [[3p1s]], [[3spr]], [[3smk]], [[3sml]], [[3smm]], [[3smn]], [[3smo]] – hPRS (mutant) + TASK-3 peptide + stabilizer<br />
-
[[4hqw]], [[4hru]] – hPRS + molecular tweezers<br />
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**[[3iqv]], [[3o8i]] – hPRS + Raf-1 peptide + stabilizer<br />
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''14-3-3 protein σ ternary complex with stabilizer''
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*14-3-3 protein ζ
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[[3p1o]], [[3ux0]], [[4fr3]] – hPRS + TASK-3 peptide + stabilizer<br />
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**[[1a4o]] – bPRS - bovine<br />
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[[3p1q]], [[3p1s]], [[3spr]], [[3smk]], [[3sml]], [[3smm]], [[3smn]], [[3smo]] – hPRS (mutant) + TASK-3 peptide + stabilizer<br />
+
**[[1a37]] – bPRS + Raf peptide <br />
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[[3iqv]], [[3o8i]] – hPRS + Raf-1 peptide + stabilizer<br />
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**[[1a38]] – bPRS + R18 peptide <br />
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===14-3-3 protein ζ===
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*14-3-3 protein ζ/δ
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[[1a4o]] – bPRS - bovine<br />
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**[[3rdh]] – hPRS <br />
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[[1a37]] – bPRS + Raf peptide <br />
+
**[[1qja]], [[1qjb]] – hPRS + phosphopeptide <br />
-
[[1a38]] – bPRS + R18 peptide <br />
+
**[[2c1j]], [[2c1n]] – hPRS + histone H3 peptide <br />
 +
**[[2o02]], [[4n7g]], [[4n7y]], [[4n84]] – hPRS + exoenzyme S peptide <br />
 +
**[[2v7d]], [[4hkc]] – hPRS + integrin peptide <br />
 +
**[[3cu8]], [[3nkx]], [[4fj3]], [[4ihl]] – hPRS + Raf-1 peptide <br />
 +
**[[2wh0]] – hPRS + protein kinase C ε peptide <br />
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**[[4bg6]] – hPRS + RND3 peptide <br />
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**[[1ib1]] – hPRS + serotonin N-acetyltransferase <br />
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===14-3-3 protein ζ/δ===
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*14-3-3 protein γ
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[[3rdh]] – hPRS <br />
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**[[4e2e]] – hPRS <br />
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[[1qja]], [[1qjb]] – hPRS + phosphopeptide <br />
+
**[[2b05]] – hPRS + phosphopeptide <br />
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[[2c1j]], [[2c1n]] – hPRS + histone H3 peptide <br />
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**[[3uzd]] – hPRS + histone deacylase peptide <br />
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[[2o02]], [[4n7g]], [[4n7y]], [[4n84]] – hPRS + exoenzyme S peptide <br />
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**[[4j6s]] – hPRS + tyrosine hydroxylase peptide <br />
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[[2v7d]], [[4hkc]] – hPRS + integrin peptide <br />
+
**[[4o46]] – hPRS + influenza C-terminal peptide <br />
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[[3cu8]], [[3nkx]], [[4fj3]], [[4ihl]] – hPRS + Raf-1 peptide <br />
+
-
[[2wh0]] – hPRS + protein kinase C ε peptide <br />
+
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[[4bg6]] – hPRS + RND3 peptide <br />
+
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[[1ib1]] – hPRS + serotonin N-acetyltransferase <br />
+
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===14-3-3 protein γ===
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*14-3-3 protein β/α
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[[4e2e]] – hPRS <br />
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**[[2bq0]], [[4dnk]] – hPRS <br />
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[[2b05]] – hPRS + phosphopeptide <br />
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**[[2c23]] – hPRS + exoenzyme S peptide <br />
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[[3uzd]] – hPRS + histone deacylase peptide <br />
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**[[4gnt]] – PRS + CHREBP peptide - mouse<br />
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[[4j6s]] – hPRS + tyrosine hydroxylase peptide <br />
+
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[[4o46]] – hPRS + influenza C-terminal peptide <br />
+
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===14-3-3 protein β/α===
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*14-3-3 protein θ
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[[2bq0]], [[4dnk]] – hPRS <br />
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**[[2btp]] – hPRS + phosphopeptide <br />
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[[2c23]] – hPRS + exoenzyme S peptide <br />
+
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[[4gnt]] – PRS + CHREBP peptide - mouse<br />
+
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===14-3-3 protein θ===
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*14-3-3 protein η
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[[2btp]] – hPRS + phosphopeptide <br />
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**[[2c63]], [[2c74]] – hPRS + phosphopeptide <br />
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===14-3-3 protein η===
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*14-3-3 protein ε
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[[2c63]], [[2c74]] – hPRS + phosphopeptide <br />
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**[[2br9]] – hPRS + phosphopeptide <br />
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**[[3ual]], [[3ubw]] – hPRS + myeloid leukemia factor 1 peptide <br />
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===14-3-3 protein ε===
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*14-3-3 protein
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[[2br9]] – hPRS + phosphopeptide <br />
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**[[3efz]] – PRS + phosphoserine – ''Cryptosporidium parvum''<br />
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[[3ual]], [[3ubw]] – hPRS + myeloid leukemia factor 1 peptide <br />
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**[[4f7r]] – PRS – ''Giardia intestinalis''<br />
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===14-3-3 protein===
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-
 
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[[3efz]] – PRS + phosphoserine – ''Cryptosporidium parvum''<br />
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[[4f7r]] – PRS – ''Giardia intestinalis''<br />
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Revision as of 11:12, 11 November 2014

Structure of human 14-3-3 protein σ complex with Raf-1 peptide (green) and stabilizer (PDB code 3o8i).

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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