1iva
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1iva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agelenopsis_aperta Agelenopsis aperta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IVA FirstGlance]. <br> | <table><tr><td colspan='2'>[[1iva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agelenopsis_aperta Agelenopsis aperta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IVA FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iva RCSB], [http://www.ebi.ac.uk/pdbsum/1iva PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iva RCSB], [http://www.ebi.ac.uk/pdbsum/1iva PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TOG4A_AGEAP TOG4A_AGEAP]] Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons.<ref>PMID:1311418</ref> <ref>PMID:8250902</ref> <ref>PMID:7898748</ref> <ref>PMID:9129813</ref> <ref>PMID:9120560</ref> <ref>PMID:11055992</ref> <ref>PMID:11522785</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Agelenopsis aperta]] | [[Category: Agelenopsis aperta]] | ||
| - | [[Category: Holub, K E | + | [[Category: Holub, K E]] |
| - | [[Category: Reily, M D | + | [[Category: Reily, M D]] |
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
Revision as of 14:07, 25 December 2014
STRUCTURE-ACTIVITY RELATIONSHIPS FOR P-TYPE CALCIUM CHANNEL SELECTIVE OMEGA-AGATOXINS
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