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1lhn
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1lhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LHN FirstGlance]. <br> | <table><tr><td colspan='2'>[[1lhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LHN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AON:5-ALPHA-ANDROSTANE-3-BETA,17-ALPHA-DIOL'>AON</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AON:5-ALPHA-ANDROSTANE-3-BETA,17-ALPHA-DIOL'>AON</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d2s|1d2s]], [[1f5f|1f5f]], [[1kdk|1kdk]], [[1kdm|1kdm]], [[1lho|1lho]], [[1lhu|1lhu]], [[1lhv|1lhv]], [[1lhw|1lhw]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d2s|1d2s]], [[1f5f|1f5f]], [[1kdk|1kdk]], [[1kdm|1kdm]], [[1lho|1lho]], [[1lhu|1lhu]], [[1lhv|1lhv]], [[1lhw|1lhw]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lhn RCSB], [http://www.ebi.ac.uk/pdbsum/1lhn PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lhn RCSB], [http://www.ebi.ac.uk/pdbsum/1lhn PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SHBG_HUMAN SHBG_HUMAN]] Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Avvakumov, G V | + | [[Category: Avvakumov, G V]] |
| - | [[Category: Catalano, M G | + | [[Category: Catalano, M G]] |
| - | [[Category: Grishkovskaya, I | + | [[Category: Grishkovskaya, I]] |
| - | [[Category: Hammond, G L | + | [[Category: Hammond, G L]] |
| - | [[Category: Muller, Y A | + | [[Category: Muller, Y A]] |
[[Category: 17a-dha]] | [[Category: 17a-dha]] | ||
[[Category: Shbg]] | [[Category: Shbg]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 07:15, 25 December 2014
CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL
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