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1lxl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1lxl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LXL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1lxl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LXL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lxl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lxl RCSB], [http://www.ebi.ac.uk/pdbsum/1lxl PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lxl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lxl RCSB], [http://www.ebi.ac.uk/pdbsum/1lxl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Chang, B S | + | [[Category: Chang, B S]] |
| - | [[Category: Fesik, S W | + | [[Category: Fesik, S W]] |
| - | [[Category: Harlan, J E | + | [[Category: Harlan, J E]] |
| - | [[Category: Liang, H | + | [[Category: Liang, H]] |
| - | [[Category: Meadows, R P | + | [[Category: Meadows, R P]] |
| - | [[Category: Muchmore, S W | + | [[Category: Muchmore, S W]] |
| - | [[Category: Nettesheim, D | + | [[Category: Nettesheim, D]] |
| - | [[Category: Ng, S C | + | [[Category: Ng, S C]] |
| - | [[Category: Sattler, M | + | [[Category: Sattler, M]] |
| - | [[Category: Thompson, C B | + | [[Category: Thompson, C B]] |
| - | [[Category: Wong, S L | + | [[Category: Wong, S L]] |
| - | [[Category: Yoon, H S | + | [[Category: Yoon, H S]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bcl-2 family]] | [[Category: Bcl-2 family]] | ||
[[Category: Programmed cell death]] | [[Category: Programmed cell death]] | ||
Revision as of 12:06, 25 December 2014
NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
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