1lt7
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1lt7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LT7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1lt7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LT7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lt8|1lt8]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lt8|1lt8]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine--homocysteine_S-methyltransferase Betaine--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.5 2.1.1.5] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine--homocysteine_S-methyltransferase Betaine--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.5 2.1.1.5] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lt7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lt7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lt7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lt7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lt7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BHMT1_HUMAN BHMT1_HUMAN]] Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 34: | ||
[[Category: Betaine--homocysteine S-methyltransferase]] | [[Category: Betaine--homocysteine S-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Castro, C | + | [[Category: Castro, C]] |
| - | [[Category: Evans, J C | + | [[Category: Evans, J C]] |
| - | [[Category: Garrow, T A | + | [[Category: Garrow, T A]] |
| - | [[Category: Huddler, D P | + | [[Category: Huddler, D P]] |
| - | [[Category: Jiracek, J | + | [[Category: Jiracek, J]] |
| - | [[Category: Ludwig, M L | + | [[Category: Ludwig, M L]] |
| - | [[Category: Millian, N S | + | [[Category: Millian, N S]] |
[[Category: Homocysteine metabolism]] | [[Category: Homocysteine metabolism]] | ||
[[Category: Homocysteinemia]] | [[Category: Homocysteinemia]] | ||
[[Category: Thiol alkyl transfer]] | [[Category: Thiol alkyl transfer]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 03:45, 25 December 2014
Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions
| |||||||||||
