1m1c
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m1c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_virus_l-a Saccharomyces cerevisiae virus l-a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M1C FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m1c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_virus_l-a Saccharomyces cerevisiae virus l-a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M1C FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m1c RCSB], [http://www.ebi.ac.uk/pdbsum/1m1c PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m1c RCSB], [http://www.ebi.ac.uk/pdbsum/1m1c PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GAG_SCVLA GAG_SCVLA]] Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 40 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm.<ref>PMID:1630453</ref> <ref>PMID:7739557</ref> Binds and removes 5' cap structures from cellular mRNA. Forms a covalent bond with m7GMP through His-154 of the capsid protein while releasing the mRNA body.<ref>PMID:1630453</ref> <ref>PMID:7739557</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae virus l-a]] | [[Category: Saccharomyces cerevisiae virus l-a]] | ||
| - | [[Category: Canady, M | + | [[Category: Canady, M]] |
| - | [[Category: Johnson, J E | + | [[Category: Johnson, J E]] |
| - | [[Category: Naitow, H | + | [[Category: Naitow, H]] |
| - | [[Category: Tang, J | + | [[Category: Tang, J]] |
| - | [[Category: Wickner, R B | + | [[Category: Wickner, R B]] |
[[Category: Dsrna virus structure]] | [[Category: Dsrna virus structure]] | ||
[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
Revision as of 23:24, 24 December 2014
Structure of the L-A virus
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