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1o0p
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1o0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O0P FirstGlance]. <br> | <table><tr><td colspan='2'>[[1o0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O0P FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o0p RCSB], [http://www.ebi.ac.uk/pdbsum/1o0p PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o0p RCSB], [http://www.ebi.ac.uk/pdbsum/1o0p PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Gregorovic, G | + | [[Category: Gregorovic, G]] |
| - | [[Category: Kramer, A | + | [[Category: Kramer, A]] |
| - | [[Category: Rhani, Z | + | [[Category: Rhani, Z]] |
| - | [[Category: Sattler, M | + | [[Category: Sattler, M]] |
| - | [[Category: Selenko, P | + | [[Category: Selenko, P]] |
| - | [[Category: Sprangers, R | + | [[Category: Sprangers, R]] |
| - | [[Category: Stier, G | + | [[Category: Stier, G]] |
| - | [[Category: | + | [[Category: Alpha helices additionally extended by a third helix c]] |
[[Category: 4-stranded anti-parallel beta-sheet]] | [[Category: 4-stranded anti-parallel beta-sheet]] | ||
[[Category: Non-canonical rna recognition motif]] | [[Category: Non-canonical rna recognition motif]] | ||
[[Category: Rna binding protein]] | [[Category: Rna binding protein]] | ||
Revision as of 12:19, 25 December 2014
Solution Structure of the third RNA Recognition Motif (RRM) of U2AF65 in complex with an N-terminal SF1 peptide
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