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1m9a
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M9A FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M9A FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gta|1gta]], [[1gtb|1gtb]], [[1gne|1gne]], [[1m99|1m99]], [[1m9b|1m9b]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gta|1gta]], [[1gtb|1gtb]], [[1gne|1gne]], [[1m99|1m99]], [[1m9b|1m9b]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m9a RCSB], [http://www.ebi.ac.uk/pdbsum/1m9a PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m9a RCSB], [http://www.ebi.ac.uk/pdbsum/1m9a PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma japonicum]] | [[Category: Schistosoma japonicum]] | ||
| - | [[Category: Bruns, C M | + | [[Category: Bruns, C M]] |
| - | [[Category: Cardoso, R M.F | + | [[Category: Cardoso, R M.F]] |
| - | [[Category: Daniels, D S | + | [[Category: Daniels, D S]] |
| - | [[Category: Tainer, J A | + | [[Category: Tainer, J A]] |
[[Category: Antigen]] | [[Category: Antigen]] | ||
| - | [[Category: Glutathione transferase]] | ||
[[Category: Multigene family]] | [[Category: Multigene family]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:11, 25 December 2014
Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with S-hexylglutathione
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