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1ms6
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS6 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms6 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms6 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Cathepsin S]] | [[Category: Cathepsin S]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bekkali, Y | + | [[Category: Bekkali, Y]] |
| - | [[Category: Brown, M L | + | [[Category: Brown, M L]] |
| - | [[Category: Crane, K | + | [[Category: Crane, K]] |
| - | [[Category: Cywin, C L | + | [[Category: Cywin, C L]] |
| - | [[Category: Davidson, W | + | [[Category: Davidson, W]] |
| - | [[Category: DeTuri, M | + | [[Category: DeTuri, M]] |
| - | [[Category: Emmanuel, M J | + | [[Category: Emmanuel, M J]] |
| - | [[Category: Freeman, D M | + | [[Category: Freeman, D M]] |
| - | [[Category: Frye, L L | + | [[Category: Frye, L L]] |
| - | [[Category: Giradot, M | + | [[Category: Giradot, M]] |
| - | [[Category: Grygon, C A | + | [[Category: Grygon, C A]] |
| - | [[Category: Hao, M H | + | [[Category: Hao, M H]] |
| - | [[Category: Hopkins, J L | + | [[Category: Hopkins, J L]] |
| - | [[Category: Hrapchak, M | + | [[Category: Hrapchak, M]] |
| - | [[Category: Labadia, M E | + | [[Category: Labadia, M E]] |
| - | [[Category: McNeil, D | + | [[Category: McNeil, D]] |
| - | [[Category: Morwick, T | + | [[Category: Morwick, T]] |
| - | [[Category: Pav, S | + | [[Category: Pav, S]] |
| - | [[Category: Spero, D M | + | [[Category: Spero, D M]] |
| - | [[Category: Thomson, D S | + | [[Category: Thomson, D S]] |
| - | [[Category: Wang, Y | + | [[Category: Wang, Y]] |
| - | [[Category: Ward, Y D | + | [[Category: Ward, Y D]] |
| - | [[Category: White, D | + | [[Category: White, D]] |
| - | [[Category: Zindell, R | + | [[Category: Zindell, R]] |
[[Category: Cathepsin]] | [[Category: Cathepsin]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
Revision as of 08:25, 25 December 2014
Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
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Categories: Cathepsin S | Homo sapiens | Bekkali, Y | Brown, M L | Crane, K | Cywin, C L | Davidson, W | DeTuri, M | Emmanuel, M J | Freeman, D M | Frye, L L | Giradot, M | Grygon, C A | Hao, M H | Hopkins, J L | Hrapchak, M | Labadia, M E | McNeil, D | Morwick, T | Pav, S | Spero, D M | Thomson, D S | Wang, Y | Ward, Y D | White, D | Zindell, R | Cathepsin | Hydrolase | Protease
