This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1mm4
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MM4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MM4 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mm5|1mm5]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mm5|1mm5]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CrcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CrcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mm4 RCSB], [http://www.ebi.ac.uk/pdbsum/1mm4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mm4 RCSB], [http://www.ebi.ac.uk/pdbsum/1mm4 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRCA_ECOLI CRCA_ECOLI]] PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16:0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3-hydroxymyristate chain at position 2 of lipid A (endotoxin). Modifications of lipid A with a palmitate chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway. Phosphatidylglycerol (PtdGro), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer) and phosphatidic acid (Ptd-OH) are all effective acyl donors.<ref>PMID:11013210</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Bishop, R E | + | [[Category: Bishop, R E]] |
| - | [[Category: Chen, L | + | [[Category: Chen, L]] |
| - | [[Category: Choy, W Y | + | [[Category: Choy, W Y]] |
| - | [[Category: Forman-Kay, J D | + | [[Category: Forman-Kay, J D]] |
| - | [[Category: Hwang, P M | + | [[Category: Hwang, P M]] |
| - | [[Category: Kay, L E | + | [[Category: Kay, L E]] |
| - | [[Category: Lo, E I | + | [[Category: Lo, E I]] |
| - | [[Category: Prive, G G | + | [[Category: Prive, G G]] |
| - | [[Category: Raetz, C R.H | + | [[Category: Raetz, C R.H]] |
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Palmitoyltransferase]] | [[Category: Palmitoyltransferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 09:09, 25 December 2014
Solution NMR structure of the outer membrane enzyme PagP in DPC micelles
| |||||||||||
