1mf4

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1mf4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MF4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1mf4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MF4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lff|1lff]], [[1ln8|1ln8]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lff|1lff]], [[1ln8|1ln8]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mf4 RCSB], [http://www.ebi.ac.uk/pdbsum/1mf4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mf4 RCSB], [http://www.ebi.ac.uk/pdbsum/1mf4 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PA23_NAJSG PA23_NAJSG]] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
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[[Category: Dey, S.]]
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[[Category: Dey, S]]
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[[Category: Jabeen, T.]]
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[[Category: Jabeen, T]]
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[[Category: Kaur, P.]]
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[[Category: Kaur, P]]
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[[Category: Makker, J.]]
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[[Category: Makker, J]]
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[[Category: Paramsivam, M.]]
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[[Category: Paramsivam, M]]
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[[Category: Sharma, S.]]
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[[Category: Sharma, S]]
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[[Category: Singh, R K.]]
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[[Category: Singh, R K]]
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[[Category: Singh, T P.]]
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[[Category: Singh, T P]]
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[[Category: Srinivasan, A.]]
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[[Category: Srinivasan, A]]
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[[Category: Vikram, P.]]
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[[Category: Vikram, P]]
[[Category: Designed inhibitor]]
[[Category: Designed inhibitor]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Naja naja sagittifera]]
[[Category: Naja naja sagittifera]]
[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]

Revision as of 22:45, 25 December 2014

Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution

1mf4, resolution 1.90Å

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