This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1six
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1six]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SIX FirstGlance]. <br> | <table><tr><td colspan='2'>[[1six]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SIX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mq7|1mq7]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mq7|1mq7]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1six FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1six OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1six RCSB], [http://www.ebi.ac.uk/pdbsum/1six PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1six FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1six OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1six RCSB], [http://www.ebi.ac.uk/pdbsum/1six PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 36: | Line 38: | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: DUTP diphosphatase]] | [[Category: DUTP diphosphatase]] | ||
| - | [[Category: Cascio, D | + | [[Category: Cascio, D]] |
| - | [[Category: Chan, S | + | [[Category: Chan, S]] |
| - | [[Category: Cho, U S | + | [[Category: Cho, U S]] |
| - | [[Category: Eisenberg, D | + | [[Category: Eisenberg, D]] |
| - | [[Category: Kim, C Y | + | [[Category: Kim, C Y]] |
| - | [[Category: Kim, M | + | [[Category: Kim, M]] |
| - | [[Category: Krupka, H | + | [[Category: Krupka, H]] |
| - | [[Category: Lekin, T | + | [[Category: Lekin, T]] |
| - | [[Category: Naranjo, C M | + | [[Category: Naranjo, C M]] |
| - | [[Category: Park, M S | + | [[Category: Park, M S]] |
| - | [[Category: Pashkov, I | + | [[Category: Pashkov, I]] |
| - | [[Category: Perry, J L | + | [[Category: Perry, J L]] |
| - | [[Category: Rogers, Y C | + | [[Category: Rogers, Y C]] |
| - | [[Category: Sawaya, M R | + | [[Category: Sawaya, M R]] |
| - | [[Category: Segelke, B | + | [[Category: Segelke, B]] |
| - | [[Category: So, M | + | [[Category: So, M]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Terwilliger, T C | + | [[Category: Terwilliger, T C]] |
| - | [[Category: Waldo, G S | + | [[Category: Waldo, G S]] |
| - | [[Category: Yeates, T O | + | [[Category: Yeates, T O]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Jelly-roll]] | [[Category: Jelly-roll]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Tbsgc]] | [[Category: Tbsgc]] | ||
Revision as of 07:09, 25 December 2014
Mycobacterium tuberculosis dUTPase complexed with magnesium and alpha,beta-imido-dUTP
| |||||||||||
Categories: Mycobacterium tuberculosis | DUTP diphosphatase | Cascio, D | Chan, S | Cho, U S | Eisenberg, D | Kim, C Y | Kim, M | Krupka, H | Lekin, T | Naranjo, C M | Park, M S | Pashkov, I | Perry, J L | Rogers, Y C | Sawaya, M R | Segelke, B | So, M | Structural genomic | Terwilliger, T C | Waldo, G S | Yeates, T O | Hydrolase | Jelly-roll | PSI, Protein structure initiative | Tbsgc
