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1vlk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VLK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1vlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VLK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vlk RCSB], [http://www.ebi.ac.uk/pdbsum/1vlk PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vlk RCSB], [http://www.ebi.ac.uk/pdbsum/1vlk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL10H_EBV IL10H_EBV]] Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Inhibits IFN-gamma synthesis.<ref>PMID:2161559</ref> <ref>PMID:9310490</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
| - | [[Category: Schalk-Hihi, C | + | [[Category: Schalk-Hihi, C]] |
| - | [[Category: Wlodawer, A | + | [[Category: Wlodawer, A]] |
| - | [[Category: Zdanov, A | + | [[Category: Zdanov, A]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
Revision as of 07:33, 25 December 2014
STRUCTURE OF VIRAL INTERLEUKIN-10
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