1fml

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|PDB= 1fml |SIZE=350|CAPTION= <scene name='initialview01'>1fml</scene>, resolution 2.75&Aring;
|PDB= 1fml |SIZE=350|CAPTION= <scene name='initialview01'>1fml</scene>, resolution 2.75&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=A3P:ADENOSINE-3'-5'-DIPHOSPHATE'>A3P</scene> and <scene name='pdbligand=RTL:RETINOL'>RTL</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene> and <scene name='pdbligand=RTL:RETINOL'>RTL</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: sulfotransferase]]
[[Category: sulfotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:11:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:48:25 2008''

Revision as of 09:48, 23 March 2008

Image:1fml.gif


PDB ID 1fml

Drag the structure with the mouse to rotate
, resolution 2.75Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP


Overview

We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.

About this Structure

1FML is a Single protein structure of sequence from Spodoptera frugiperda. Full crystallographic information is available from OCA.

Reference

A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:11323722

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