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1t9s
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T9S FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T9S FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t9r|1t9r]], [[1taz|1taz]], [[1tb5|1tb5]], [[1tb7|1tb7]], [[1tbb|1tbb]], [[1tbf|1tbf]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t9r|1t9r]], [[1taz|1taz]], [[1tb5|1tb5]], [[1tb7|1tb7]], [[1tbb|1tbb]], [[1tbf|1tbf]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t9s RCSB], [http://www.ebi.ac.uk/pdbsum/1t9s PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t9s RCSB], [http://www.ebi.ac.uk/pdbsum/1t9s PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | [[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Artis, D R | + | [[Category: Artis, D R]] |
| - | [[Category: Bollag, G | + | [[Category: Bollag, G]] |
| - | [[Category: Card, G L | + | [[Category: Card, G L]] |
| - | [[Category: Fong, D | + | [[Category: Fong, D]] |
| - | [[Category: Gillette, S | + | [[Category: Gillette, S]] |
| - | [[Category: Hsieh, D | + | [[Category: Hsieh, D]] |
| - | [[Category: Kim, S H | + | [[Category: Kim, S H]] |
| - | [[Category: Milburn, M V | + | [[Category: Milburn, M V]] |
| - | [[Category: Neiman, J | + | [[Category: Neiman, J]] |
| - | [[Category: Schlessinger, J | + | [[Category: Schlessinger, J]] |
| - | [[Category: Suzuki, Y | + | [[Category: Suzuki, Y]] |
| - | [[Category: West, B L | + | [[Category: West, B L]] |
| - | [[Category: Zhang, C | + | [[Category: Zhang, C]] |
| - | [[Category: Zhang, K Y.J | + | [[Category: Zhang, K Y.J]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Pde5a]] | [[Category: Pde5a]] | ||
Revision as of 00:29, 25 December 2014
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP
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