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1udu
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1udu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UDU FirstGlance]. <br> | <table><tr><td colspan='2'>[[1udu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UDU FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1udt|1udt]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1udt|1udt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1udu RCSB], [http://www.ebi.ac.uk/pdbsum/1udu PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1udu RCSB], [http://www.ebi.ac.uk/pdbsum/1udu PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | [[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cho, J M | + | [[Category: Cho, J M]] |
| - | [[Category: Eum, S J | + | [[Category: Eum, S J]] |
| - | [[Category: Heo, Y S | + | [[Category: Heo, Y S]] |
| - | [[Category: Hwang, K Y | + | [[Category: Hwang, K Y]] |
| - | [[Category: Hyun, Y L | + | [[Category: Hyun, Y L]] |
| - | [[Category: Jeon, Y H | + | [[Category: Jeon, Y H]] |
| - | [[Category: Kim, E | + | [[Category: Kim, E]] |
| - | [[Category: Kim, J H | + | [[Category: Kim, J H]] |
| - | [[Category: Lee, J I | + | [[Category: Lee, J I]] |
| - | [[Category: Lee, J O | + | [[Category: Lee, J O]] |
| - | [[Category: Lee, T G | + | [[Category: Lee, T G]] |
| - | [[Category: Moon, J | + | [[Category: Moon, J]] |
| - | [[Category: Park, S Y | + | [[Category: Park, S Y]] |
| - | [[Category: Ro, S | + | [[Category: Ro, S]] |
| - | [[Category: Sung, B J | + | [[Category: Sung, B J]] |
| - | [[Category: Yoon, J M | + | [[Category: Yoon, J M]] |
[[Category: Cgmp-specific phosphodiesterase 5]] | [[Category: Cgmp-specific phosphodiesterase 5]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Selective inhibitor]] | [[Category: Selective inhibitor]] | ||
[[Category: Tadalafil]] | [[Category: Tadalafil]] | ||
Revision as of 09:21, 25 December 2014
Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)
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Categories: 3',5'-cyclic-nucleotide phosphodiesterase | Homo sapiens | Cho, J M | Eum, S J | Heo, Y S | Hwang, K Y | Hyun, Y L | Jeon, Y H | Kim, E | Kim, J H | Lee, J I | Lee, J O | Lee, T G | Moon, J | Park, S Y | Ro, S | Sung, B J | Yoon, J M | Cgmp-specific phosphodiesterase 5 | Hydrolase | Selective inhibitor | Tadalafil
