1pa0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1pa0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothropoides_pauloensis Bothropoides pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PA0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1pa0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothropoides_pauloensis Bothropoides pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PA0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pa0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pa0 RCSB], [http://www.ebi.ac.uk/pdbsum/1pa0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pa0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pa0 RCSB], [http://www.ebi.ac.uk/pdbsum/1pa0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PA2H_BOTNE PA2H_BOTNE]] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.<ref>PMID:10860537</ref> <ref>PMID:9972319</ref> <ref>PMID:14623331</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bothropoides pauloensis]] | [[Category: Bothropoides pauloensis]] | ||
| - | [[Category: Fontes, M R | + | [[Category: Fontes, M R]] |
| - | [[Category: Giglio, J R | + | [[Category: Giglio, J R]] |
| - | [[Category: Magro, A J | + | [[Category: Magro, A J]] |
| - | [[Category: Soares, A M | + | [[Category: Soares, A M]] |
[[Category: Bothropic venom]] | [[Category: Bothropic venom]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Lys49-phospholipase a2]] | [[Category: Lys49-phospholipase a2]] | ||
[[Category: Myotoxin]] | [[Category: Myotoxin]] | ||
Revision as of 15:31, 24 December 2014
CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2
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