1fqi

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|PDB= 1fqi |SIZE=350|CAPTION= <scene name='initialview01'>1fqi</scene>, resolution 1.94&Aring;
|PDB= 1fqi |SIZE=350|CAPTION= <scene name='initialview01'>1fqi</scene>, resolution 1.94&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY=
|ACTIVITY=
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|RELATEDENTRY=[[1fqj|1FQJ]], [[1fqk|1FQK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fqi OCA], [http://www.ebi.ac.uk/pdbsum/1fqi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fqi RCSB]</span>
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[[Category: rod]]
[[Category: rod]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:12:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:28:15 2008''

Revision as of 17:28, 30 March 2008

Image:1fqi.gif


PDB ID 1fqi

Drag the structure with the mouse to rotate
, resolution 1.94Å
Ligands:
Related: 1FQJ, 1FQK


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



RGS9 RGS DOMAIN


Overview

A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt, couples photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate phototransduction cascade. The interactions of the Gt alpha-subunit (alpha(t)) with the inhibitory PDE gamma-subunit (PDEgamma) are central to effector activation, and also enhance visual recovery in cooperation with the GTPase-activating protein regulator of G-protein signalling (RGS)-9 (refs 1-3). Here we describe the crystal structure at 2.0 A of rod transducin alpha x GDP x AlF4- in complex with the effector molecule PDEgamma and the GTPase-activating protein RGS9. In addition, we present the independently solved crystal structures of the RGS9 RGS domain both alone and in complex with alpha(t/i1) x GDP x AlF4-. These structures reveal insights into effector activation, synergistic GTPase acceleration, RGS9 specificity and RGS activity. Effector binding to a nucleotide-dependent site on alpha(t) sequesters PDEgamma residues implicated in PDE inhibition, and potentiates recruitment of RGS9 for hydrolytic transition state stabilization and concomitant signal termination.

About this Structure

1FQI is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A., Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB, Nature. 2001 Feb 22;409(6823):1071-7. PMID:11234020

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