1fsc
From Proteopedia
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|PDB= 1fsc |SIZE=350|CAPTION= <scene name='initialview01'>1fsc</scene>, resolution 2.0Å | |PDB= 1fsc |SIZE=350|CAPTION= <scene name='initialview01'>1fsc</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=O:OXYGEN ATOM'>O</scene> | + | |LIGAND= <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fsc OCA], [http://www.ebi.ac.uk/pdbsum/1fsc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fsc RCSB]</span> | ||
}} | }} | ||
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[[Category: Fontecilla-Camps, J C.]] | [[Category: Fontecilla-Camps, J C.]] | ||
[[Category: Housset, D.]] | [[Category: Housset, D.]] | ||
| - | [[Category: O]] | ||
[[Category: snake toxin]] | [[Category: snake toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:29:31 2008'' |
Revision as of 17:29, 30 March 2008
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| , resolution 2.0Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF FASCICULIN 2 FROM GREEN MAMBA SNAKE VENOM: EVIDENCE FOR UNUSUAL LOOP FLEXIBILITY
Overview
The crystal structure of the snake toxin fasciculin 2, a potent acetylcholinesterase inhibitor from the venom of the green mamba (Dendroaspis angusticeps), has been determined by the molecular-replacement method, using the fasciculin 1 model and refined to 2.0 A resolution. The introduction of an overall anisotropic temperature factor improved significantly the quality of the electron-density map. It suggests, as it was also indicated by the packing, that the thermal motion along the unique axis direction is less pronounced than on the (ab) plane. The final crystallographic R factor is 0.188 for a model having r.m.s. deviations from ideality of 0.016 A for bond lengths and 2.01 degrees for bond angles. As fasciculin 1, fasciculin 2 belongs to the three-finger class of Elapidae toxins, a structural group that also contains the alpha-neurotoxins and the cardiotoxins. Although the two fasciculins have, overall, closely related structures, the conformation of loop I differs appreciably in the two molecules. The presence of detergent in crystallization medium in the case of fasciculin 2 appears to be responsible for the displacement of the loop containing Thr9. This conformational change also results in the formation of a crystallographic dimer that displays extensive intermolecular interactions.
About this Structure
1FSC is a Single protein structure of sequence from Dendroaspis angusticeps. Full crystallographic information is available from OCA.
Reference
Structure of fasciculin 2 from green mamba snake venom: evidence for unusual loop flexibility., le Du MH, Housset D, Marchot P, Bougis PE, Navaza J, Fontecilla-Camps JC, Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):87-92. PMID:15299729
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