2o2m
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2o2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O2M FirstGlance]. <br> | <table><tr><td colspan='2'>[[2o2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O2M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o2m RCSB], [http://www.ebi.ac.uk/pdbsum/2o2m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o2m RCSB], [http://www.ebi.ac.uk/pdbsum/2o2m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCLX_HUMAN BCLX_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Belli, B A | + | [[Category: Belli, B A]] |
| - | [[Category: Bruncko, M | + | [[Category: Bruncko, M]] |
| - | [[Category: Ding, H | + | [[Category: Ding, H]] |
| - | [[Category: Elmore, S W | + | [[Category: Elmore, S W]] |
| - | [[Category: Fesik, S W | + | [[Category: Fesik, S W]] |
| - | [[Category: Joseph, M K | + | [[Category: Joseph, M K]] |
| - | [[Category: Kunzer, A | + | [[Category: Kunzer, A]] |
| - | [[Category: Martineau, D | + | [[Category: Martineau, D]] |
| - | [[Category: McClellan, W J | + | [[Category: McClellan, W J]] |
| - | [[Category: Mitten, M | + | [[Category: Mitten, M]] |
| - | [[Category: Ng, S C | + | [[Category: Ng, S C]] |
| - | [[Category: Nimmer, P M | + | [[Category: Nimmer, P M]] |
| - | [[Category: Oltersdorf, T | + | [[Category: Oltersdorf, T]] |
| - | [[Category: Oost, T K | + | [[Category: Oost, T K]] |
| - | [[Category: Park, C M | + | [[Category: Park, C M]] |
| - | [[Category: Petros, A M | + | [[Category: Petros, A M]] |
| - | [[Category: Rosenberg, S H | + | [[Category: Rosenberg, S H]] |
| - | [[Category: Shoemaker, A R | + | [[Category: Shoemaker, A R]] |
| - | [[Category: Song, X | + | [[Category: Song, X]] |
| - | [[Category: Wang, X | + | [[Category: Wang, X]] |
| - | [[Category: Wendt, M D | + | [[Category: Wendt, M D]] |
| - | [[Category: Zhang, H | + | [[Category: Zhang, H]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bcl]] | [[Category: Bcl]] | ||
[[Category: Complex]] | [[Category: Complex]] | ||
Revision as of 17:32, 24 December 2014
Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand
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Categories: Homo sapiens | Belli, B A | Bruncko, M | Ding, H | Elmore, S W | Fesik, S W | Joseph, M K | Kunzer, A | Martineau, D | McClellan, W J | Mitten, M | Ng, S C | Nimmer, P M | Oltersdorf, T | Oost, T K | Park, C M | Petros, A M | Rosenberg, S H | Shoemaker, A R | Song, X | Wang, X | Wendt, M D | Zhang, H | Apoptosis | Bcl | Complex
