2a3j
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2a3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3J FirstGlance]. <br> | <table><tr><td colspan='2'>[[2a3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3J FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a3j RCSB], [http://www.ebi.ac.uk/pdbsum/2a3j PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a3j RCSB], [http://www.ebi.ac.uk/pdbsum/2a3j PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Baker, D | + | [[Category: Baker, D]] |
| - | [[Category: Dantas, G | + | [[Category: Dantas, G]] |
| - | [[Category: Dobson, N | + | [[Category: Dobson, N]] |
| - | [[Category: Varani, G | + | [[Category: Varani, G]] |
[[Category: Computationally designed protein]] | [[Category: Computationally designed protein]] | ||
[[Category: Rna binding protein]] | [[Category: Rna binding protein]] | ||
[[Category: Rrm]] | [[Category: Rrm]] | ||
[[Category: U1a]] | [[Category: U1a]] | ||
Revision as of 11:37, 25 December 2014
Structure of URNdesign, a complete computational redesign of human U1A protein
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