2gw6
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GW6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GW6 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSEN15, C1orf19, SEN15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSEN15, C1orf19, SEN15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gw6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gw6 PDBsum], [http://www.topsan.org/Proteins/CESG/2gw6 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gw6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gw6 PDBsum], [http://www.topsan.org/Proteins/CESG/2gw6 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SEN15_HUMAN SEN15_HUMAN]] Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.<ref>PMID:15109492</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Markley, J L | + | [[Category: Markley, J L]] |
| - | [[Category: Song, J | + | [[Category: Song, J]] |
| - | + | ||
[[Category: Cesg]] | [[Category: Cesg]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Sen15_human]] | [[Category: Sen15_human]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Trna endonuclease]] | [[Category: Trna endonuclease]] | ||
Revision as of 07:42, 24 December 2014
NMR structure of the human tRNA endonuclease SEN15 subunit
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