2ivx

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ivx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IVX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ivx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IVX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ivx RCSB], [http://www.ebi.ac.uk/pdbsum/2ivx PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ivx RCSB], [http://www.ebi.ac.uk/pdbsum/2ivx PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CCNT2_HUMAN CCNT2_HUMAN]] Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).<ref>PMID:10364329</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith, C]]
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[[Category: Berridge, G.]]
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[[Category: Berridge, G]]
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[[Category: Bullock, A N.]]
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[[Category: Bullock, A N]]
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[[Category: Das, S.]]
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[[Category: Das, S]]
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[[Category: Debreczeni, J E.]]
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[[Category: Debreczeni, J E]]
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[[Category: Delft, F Von.]]
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[[Category: Delft, F Von]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov, O]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec, F]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou, E]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike, A C.W]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky, P]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull, A.]]
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[[Category: Turnbull, A]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cell division]]

Revision as of 19:54, 25 December 2014

CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION (CASP TARGET)

2ivx, resolution 1.80Å

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