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2byp
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2byp]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BYP FirstGlance]. <br> | <table><tr><td colspan='2'>[[2byp]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BYP FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cnl|1cnl]], [[1e74|1e74]], [[1e75|1e75]], [[1e76|1e76]], [[1g2g|1g2g]], [[1im1|1im1]], [[1imi|1imi]], [[2br7|2br7]], [[2br8|2br8]], [[2byn|2byn]], [[2byq|2byq]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cnl|1cnl]], [[1e74|1e74]], [[1e75|1e75]], [[1e76|1e76]], [[1g2g|1g2g]], [[1im1|1im1]], [[1imi|1imi]], [[2br7|2br7]], [[2br8|2br8]], [[2byn|2byn]], [[2byq|2byq]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2byp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2byp RCSB], [http://www.ebi.ac.uk/pdbsum/2byp PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2byp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2byp RCSB], [http://www.ebi.ac.uk/pdbsum/2byp PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Aplysia californica]] | [[Category: Aplysia californica]] | ||
| - | [[Category: Bourne, Y | + | [[Category: Bourne, Y]] |
| - | [[Category: Hansen, S B | + | [[Category: Hansen, S B]] |
| - | [[Category: Huxford, T | + | [[Category: Huxford, T]] |
| - | [[Category: Marchot, P | + | [[Category: Marchot, P]] |
| - | [[Category: Sulzenbacher, G | + | [[Category: Sulzenbacher, G]] |
| - | [[Category: Taylor, P | + | [[Category: Taylor, P]] |
[[Category: Conotoxin]] | [[Category: Conotoxin]] | ||
[[Category: Nicotinic acetylcholine receptor complex]] | [[Category: Nicotinic acetylcholine receptor complex]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Receptor complex]] | [[Category: Receptor complex]] | ||
Revision as of 03:43, 25 December 2014
CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH ALPHA-CONOTOXIN IMI
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