2jle

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jle]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JLE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jle]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JLE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I15:5-[(5-FLUORO-3-METHYL-1H-INDAZOL-4-YL)OXY]BENZENE-1,3-DICARBONITRILE'>I15</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I15:5-[(5-FLUORO-3-METHYL-1H-INDAZOL-4-YL)OXY]BENZENE-1,3-DICARBONITRILE'>I15</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jle OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jle RCSB], [http://www.ebi.ac.uk/pdbsum/2jle PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jle OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jle RCSB], [http://www.ebi.ac.uk/pdbsum/2jle PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Allan, G.]]
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[[Category: Allan, G]]
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[[Category: Barba, O.]]
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[[Category: Barba, O]]
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[[Category: Burt, C.]]
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[[Category: Burt, C]]
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[[Category: Corbau, R.]]
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[[Category: Corbau, R]]
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[[Category: Dupont, T.]]
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[[Category: Dupont, T]]
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[[Category: Irving, S.]]
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[[Category: Irving, S]]
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[[Category: Jones, L H.]]
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[[Category: Jones, L H]]
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[[Category: Mowbray, C E.]]
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[[Category: Mowbray, C E]]
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[[Category: Phillips, C.]]
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[[Category: Phillips, C]]
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[[Category: Swain, N A.]]
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[[Category: Swain, N A]]
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[[Category: Webster, R.]]
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[[Category: Webster, R]]
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[[Category: Westby, M.]]
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[[Category: Westby, M]]
[[Category: Aid]]
[[Category: Aid]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]

Revision as of 17:13, 19 January 2015

NOVEL INDAZOLE NNRTIS CREATED USING MOLECULAR TEMPLATE HYBRIDIZATION BASED ON CRYSTALLOGRAPHIC OVERLAYS

2jle, resolution 2.90Å

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