1zn1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zn1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZN1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1zn1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZN1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p6g|1p6g]], [[1p85|1p85]], [[1ek8|1ek8]], [[1zn0|1zn0]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p6g|1p6g]], [[1p85|1p85]], [[1ek8|1ek8]], [[1zn0|1zn0]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zn1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zn1 RCSB], [http://www.ebi.ac.uk/pdbsum/1zn1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zn1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zn1 RCSB], [http://www.ebi.ac.uk/pdbsum/1zn1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RS12_ECOLI RS12_ECOLI]] With S4 and S5 plays an important role in translational accuracy.[HAMAP-Rule:MF_00403_B] Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).[HAMAP-Rule:MF_00403_B] Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit.[HAMAP-Rule:MF_00403_B] [[http://www.uniprot.org/uniprot/RRF_ECOLI RRF_ECOLI]] Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.[HAMAP-Rule:MF_00040] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Ehrenberg, M | + | [[Category: Ehrenberg, M]] |
| - | [[Category: Frank, J | + | [[Category: Frank, J]] |
| - | [[Category: Gao, N | + | [[Category: Gao, N]] |
| - | [[Category: Gursky, R P | + | [[Category: Gursky, R P]] |
| - | [[Category: Li, W | + | [[Category: Li, W]] |
| - | [[Category: Sengupta, J | + | [[Category: Sengupta, J]] |
| - | [[Category: Valle, M | + | [[Category: Valle, M]] |
| - | [[Category: Zavialov, A V | + | [[Category: Zavialov, A V]] |
| - | + | ||
[[Category: Biosynthetic-structural protein-rna complex]] | [[Category: Biosynthetic-structural protein-rna complex]] | ||
[[Category: Elongation factor g]] | [[Category: Elongation factor g]] | ||
[[Category: Post-termination complex]] | [[Category: Post-termination complex]] | ||
[[Category: Ribosome recycling factor]] | [[Category: Ribosome recycling factor]] | ||
Revision as of 21:16, 25 December 2014
Coordinates of RRF fitted into Cryo-EM map of the 70S post-termination complex
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