2h5x

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2h5x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H5X FirstGlance]. <br>
<table><tr><td colspan='2'>[[2h5x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H5X FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ruvA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ruvA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB], [http://www.ebi.ac.uk/pdbsum/2h5x PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB], [http://www.ebi.ac.uk/pdbsum/2h5x PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RUVA_MYCTU RUVA_MYCTU]] The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Alipio, E Z.]]
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[[Category: Alipio, E Z]]
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[[Category: Bursey, E.]]
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[[Category: Bursey, E]]
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[[Category: Chandra, N R.]]
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[[Category: Chandra, N R]]
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[[Category: Hung, L W.]]
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[[Category: Hung, L W]]
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[[Category: Khanduja, J S.]]
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[[Category: Khanduja, J S]]
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[[Category: Kim, C Y.]]
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[[Category: Kim, C Y]]
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[[Category: Lekin, T.]]
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[[Category: Lekin, T]]
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[[Category: Muniyappa, K.]]
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[[Category: Muniyappa, K]]
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[[Category: Prabu, J R.]]
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[[Category: Prabu, J R]]
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[[Category: Segelke, B.]]
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[[Category: Segelke, B]]
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[[Category: Terwilliger, T C.]]
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[[Category: Terwilliger, T C]]
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[[Category: Thamotharan, S.]]
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[[Category: Thamotharan, S]]
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[[Category: Toppani, D.]]
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[[Category: Toppani, D]]
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[[Category: Vijayan, M.]]
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[[Category: Vijayan, M]]
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[[Category: Waldo, G S.]]
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[[Category: Waldo, G S]]
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[[Category: Yu, M.]]
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[[Category: Yu, M]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Holliday junction binding]]
[[Category: Holliday junction binding]]
[[Category: Recombination]]
[[Category: Recombination]]
[[Category: Ruva]]
[[Category: Ruva]]

Revision as of 17:36, 25 December 2014

RuvA from Mycobacterium tuberculosis

2h5x, resolution 2.70Å

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OCA

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