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2gc8

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2gc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GC8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2gc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GC8 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=885:1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE'>885</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=885:1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE'>885</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gc8 RCSB], [http://www.ebi.ac.uk/pdbsum/2gc8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gc8 RCSB], [http://www.ebi.ac.uk/pdbsum/2gc8 PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: Agarwal, A.]]
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[[Category: Agarwal, A]]
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[[Category: Bard, J.]]
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[[Category: Bard, J]]
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[[Category: Chopra, R.]]
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[[Category: Chopra, R]]
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[[Category: Ciszewski, G.]]
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[[Category: Ciszewski, G]]
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[[Category: Curran, K J.]]
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[[Category: Curran, K J]]
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[[Category: Ellingboe, J W.]]
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[[Category: Ellingboe, J W]]
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[[Category: Feld, B.]]
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[[Category: Feld, B]]
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[[Category: Gopalsamy, A.]]
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[[Category: Gopalsamy, A]]
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[[Category: Howe, A Y.]]
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[[Category: Howe, A Y]]
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[[Category: Krishnamurthy, G.]]
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[[Category: Krishnamurthy, G]]
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[[Category: Lim, K.]]
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[[Category: Lim, K]]
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[[Category: Mansour, T S.]]
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[[Category: Mansour, T S]]
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[[Category: Orlowski, M.]]
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[[Category: Orlowski, M]]
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[[Category: Shi, M.]]
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[[Category: Shi, M]]
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[[Category: Sukits, S F.]]
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[[Category: Sukits, S F]]
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[[Category: Svenson, K.]]
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[[Category: Svenson, K]]
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[[Category: Connell, J O.]]
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[[Category: Connell, J O]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 09:31, 16 January 2015

Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

2gc8, resolution 2.20Å

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