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2cr8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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*[[MDM2|MDM2]] | *[[MDM2|MDM2]] | ||
*[[MDM4|MDM4]] | *[[MDM4|MDM4]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hayashi, F | + | [[Category: Hayashi, F]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Zhang, H P | + | [[Category: Zhang, H P]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Double minute 4 protein]] | [[Category: Double minute 4 protein]] | ||
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[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: P53-binding protein mdm4]] | [[Category: P53-binding protein mdm4]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Zf-ranbp domain]] | [[Category: Zf-ranbp domain]] | ||
Revision as of 10:22, 25 December 2014
Solution structure of the zf-RanBP domain of p53-binding protein Mdm4
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Categories: Homo sapiens | Hayashi, F | Structural genomic | Yokoyama, S | Zhang, H P | Cell cycle | Double minute 4 protein | Mdm2-like p53-binding de protein | Mdm4 protein | Mdmx protein | National project on protein structural and functional analyse | Nppsfa | P53-binding protein mdm4 | Rsgi | Zf-ranbp domain
