2not
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2not]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Notechis_scutatus_scutatus Notechis scutatus scutatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NOT FirstGlance]. <br> | <table><tr><td colspan='2'>[[2not]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Notechis_scutatus_scutatus Notechis scutatus scutatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NOT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2not FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2not OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2not RCSB], [http://www.ebi.ac.uk/pdbsum/2not PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2not FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2not OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2not RCSB], [http://www.ebi.ac.uk/pdbsum/2not PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PA23_NOTSC PA23_NOTSC]] Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Notechis II-5 is less toxic than notexin but has a higher specific phospholipase activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Notechis scutatus scutatus]] | [[Category: Notechis scutatus scutatus]] | ||
| - | [[Category: Carredano, E | + | [[Category: Carredano, E]] |
| - | [[Category: Eaker, D | + | [[Category: Eaker, D]] |
| - | [[Category: Eklund, H | + | [[Category: Eklund, H]] |
| - | [[Category: Persson, B | + | [[Category: Persson, B]] |
| - | [[Category: Ramaswamy, S | + | [[Category: Ramaswamy, S]] |
| - | [[Category: Saarinen, M | + | [[Category: Saarinen, M]] |
| - | [[Category: Westerlund, B | + | [[Category: Westerlund, B]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Lipid degradation]] | [[Category: Lipid degradation]] | ||
[[Category: Presynaptic neurotoxin]] | [[Category: Presynaptic neurotoxin]] | ||
[[Category: Venom]] | [[Category: Venom]] | ||
Revision as of 18:23, 25 December 2014
NOTECHIS II-5, NEUROTOXIC PHOSPHOLIPASE A2 FROM NOTECHIS SCUTATUS SCUTATUS
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