2orx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2orx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORX FirstGlance]. <br> | <table><tr><td colspan='2'>[[2orx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ORX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nrp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nrp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2orx RCSB], [http://www.ebi.ac.uk/pdbsum/2orx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2orx RCSB], [http://www.ebi.ac.uk/pdbsum/2orx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NRP1_RAT NRP1_RAT]] Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Bellamy, H D | + | [[Category: Bellamy, H D]] |
| - | [[Category: Jusino, M A | + | [[Category: Jusino, M A]] |
| - | [[Category: Kooi, C W.Vander | + | [[Category: Kooi, C W.Vander]] |
| - | [[Category: Leahy, D J | + | [[Category: Leahy, D J]] |
| - | [[Category: Neau, D B | + | [[Category: Neau, D B]] |
| - | [[Category: Perman, B | + | [[Category: Perman, B]] |
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Neuropilin]] | [[Category: Neuropilin]] | ||
Revision as of 06:57, 25 December 2014
Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
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