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2r9m
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2r9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9M FirstGlance]. <br> | <table><tr><td colspan='2'>[[2r9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y11:N-[(1S)-2-[(4-CYANO-1-METHYLPIPERIDIN-4-YL)AMINO]-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y11</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y11:N-[(1S)-2-[(4-CYANO-1-METHYLPIPERIDIN-4-YL)AMINO]-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y11</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r9n|2r9n]], [[2r9o|2r9o]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r9n|2r9n]], [[2r9o|2r9o]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9m RCSB], [http://www.ebi.ac.uk/pdbsum/2r9m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9m RCSB], [http://www.ebi.ac.uk/pdbsum/2r9m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Cathepsin S]] | [[Category: Cathepsin S]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bekkali, Y | + | [[Category: Bekkali, Y]] |
| - | [[Category: Brown, M L | + | [[Category: Brown, M L]] |
| - | [[Category: Capolino, A | + | [[Category: Capolino, A]] |
| - | [[Category: Crane, K M | + | [[Category: Crane, K M]] |
| - | [[Category: DeTuri, M | + | [[Category: DeTuri, M]] |
| - | [[Category: Emmanuel, M J | + | [[Category: Emmanuel, M J]] |
| - | [[Category: Freeman, D | + | [[Category: Freeman, D]] |
| - | [[Category: Frye, L L | + | [[Category: Frye, L L]] |
| - | [[Category: Girardot, M | + | [[Category: Girardot, M]] |
| - | [[Category: Grygon, C A | + | [[Category: Grygon, C A]] |
| - | [[Category: Hao, M H | + | [[Category: Hao, M H]] |
| - | [[Category: Hrapchak, M | + | [[Category: Hrapchak, M]] |
| - | [[Category: Labadia, M E | + | [[Category: Labadia, M E]] |
| - | [[Category: Liu, W | + | [[Category: Liu, W]] |
| - | [[Category: Morwick, T | + | [[Category: Morwick, T]] |
| - | [[Category: Nelson, R | + | [[Category: Nelson, R]] |
| - | [[Category: Peterson, J D | + | [[Category: Peterson, J D]] |
| - | [[Category: Raymond, E L | + | [[Category: Raymond, E L]] |
| - | [[Category: Spero, D M | + | [[Category: Spero, D M]] |
| - | [[Category: Thomson, D S | + | [[Category: Thomson, D S]] |
| - | [[Category: Wang, Y | + | [[Category: Wang, Y]] |
| - | [[Category: Ward, Y D | + | [[Category: Ward, Y D]] |
| - | [[Category: White, A | + | [[Category: White, A]] |
| - | [[Category: White, D M | + | [[Category: White, D M]] |
| - | [[Category: Wildeson, J | + | [[Category: Wildeson, J]] |
| - | [[Category: Young, E R.R | + | [[Category: Young, E R.R]] |
| - | [[Category: Zindell, R | + | [[Category: Zindell, R]] |
[[Category: Cathepsin]] | [[Category: Cathepsin]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
Revision as of 07:10, 25 December 2014
Cathepsin S complexed with Compound 15
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Categories: Cathepsin S | Homo sapiens | Bekkali, Y | Brown, M L | Capolino, A | Crane, K M | DeTuri, M | Emmanuel, M J | Freeman, D | Frye, L L | Girardot, M | Grygon, C A | Hao, M H | Hrapchak, M | Labadia, M E | Liu, W | Morwick, T | Nelson, R | Peterson, J D | Raymond, E L | Spero, D M | Thomson, D S | Wang, Y | Ward, Y D | White, A | White, D M | Wildeson, J | Young, E R.R | Zindell, R | Cathepsin | Glycoprotein | Hydrolase | Lysosome | Protease | Thiol protease | Zymogen
