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3d52
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3d52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D52 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3d52]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D52 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GHR:[[(3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)PIPERIDIN-2-YLIDENE]AMINO]+N-(4-CHLOROPHENYL)CARBAMATE'>GHR</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GHR:[[(3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)PIPERIDIN-2-YLIDENE]AMINO]+N-(4-CHLOROPHENYL)CARBAMATE'>GHR</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hty|1hty]], [[1hww|1hww]], [[1hxk|1hxk]], [[1ps2|1ps2]], [[1qwn|1qwn]], [[1qwu|1qwu]], [[1qx1|1qx1]], [[1r33|1r33]], [[1r34|1r34]], [[2alw|2alw]], [[2f7o|2f7o]], [[2f7p|2f7p]], [[2f7q|2f7q]], [[2f7r|2f7r]], [[3bub|3bub]], [[3bud|3bud]], [[3bui|3bui]], [[3bup|3bup]], [[3buq|3buq]], [[3bvt|3bvt]], [[3bvu|3bvu]], [[3bvv|3bvv]], [[3bvw|3bvw]], [[3bvx|3bvx]], [[3cv5|3cv5]], [[3czn|3czn]], [[3czs|3czs]], [[3d4y|3d4y]], [[3d4z|3d4z]], [[3d50|3d50]], [[3d51|3d51]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hty|1hty]], [[1hww|1hww]], [[1hxk|1hxk]], [[1ps2|1ps2]], [[1qwn|1qwn]], [[1qwu|1qwu]], [[1qx1|1qx1]], [[1r33|1r33]], [[1r34|1r34]], [[2alw|2alw]], [[2f7o|2f7o]], [[2f7p|2f7p]], [[2f7q|2f7q]], [[2f7r|2f7r]], [[3bub|3bub]], [[3bud|3bud]], [[3bui|3bui]], [[3bup|3bup]], [[3buq|3buq]], [[3bvt|3bvt]], [[3bvu|3bvu]], [[3bvv|3bvv]], [[3bvw|3bvw]], [[3bvx|3bvx]], [[3cv5|3cv5]], [[3czn|3czn]], [[3czs|3czs]], [[3d4y|3d4y]], [[3d4z|3d4z]], [[3d50|3d50]], [[3d51|3d51]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alpha-Man-II, GmII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d52 RCSB], [http://www.ebi.ac.uk/pdbsum/3d52 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d52 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d52 RCSB], [http://www.ebi.ac.uk/pdbsum/3d52 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MAN2_DROME MAN2_DROME]] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]] | [[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]] | ||
| - | [[Category: Kuntz, D A | + | [[Category: Kuntz, D A]] |
| - | [[Category: Rose, D R | + | [[Category: Rose, D R]] |
| - | [[Category: Tarling, C A | + | [[Category: Tarling, C A]] |
| - | [[Category: Withers, S G | + | [[Category: Withers, S G]] |
[[Category: Gh38 glycosidase]] | [[Category: Gh38 glycosidase]] | ||
[[Category: Golgi apparatus]] | [[Category: Golgi apparatus]] | ||
Revision as of 00:56, 25 December 2014
GOLGI MANNOSIDASE II complex with an N-aryl carbamate derivative of gluco-hydroxyiminolactam
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