3d4s
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3d4s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D4S FirstGlance]. <br> | <table><tr><td colspan='2'>[[3d4s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D4S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D4S FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=TIM:(2S)-1-(TERT-BUTYLAMINO)-3-[(4-MORPHOLIN-4-YL-1,2,5-THIADIAZOL-3-YL)OXY]PROPAN-2-OL'>TIM</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=TIM:(2S)-1-(TERT-BUTYLAMINO)-3-[(4-MORPHOLIN-4-YL-1,2,5-THIADIAZOL-3-YL)OXY]PROPAN-2-OL'>TIM</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rh1|2rh1]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rh1|2rh1]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR / E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR / E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d4s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d4s RCSB], [http://www.ebi.ac.uk/pdbsum/3d4s PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d4s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d4s RCSB], [http://www.ebi.ac.uk/pdbsum/3d4s PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure | + | [[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]] |
| - | [[Category: Cherezov, V | + | [[Category: Cherezov, V]] |
| - | [[Category: Chien, E Y.T | + | [[Category: Chien, E Y.T]] |
| - | [[Category: GPCR, GPCR Network | + | [[Category: GPCR, GPCR Network]] |
| - | [[Category: Griffith, M T | + | [[Category: Griffith, M T]] |
| - | [[Category: Hanson, M A | + | [[Category: Hanson, M A]] |
| - | [[Category: Jaakola, V-P | + | [[Category: Jaakola, V-P]] |
| - | [[Category: Kuhn, P | + | [[Category: Kuhn, P]] |
| - | [[Category: Roth, C B | + | [[Category: Roth, C B]] |
| - | [[Category: Stevens, R C | + | [[Category: Stevens, R C]] |
| - | [[Category: Velasquez, J | + | [[Category: Velasquez, J]] |
[[Category: Accelerated technologies center for gene to 3d structure]] | [[Category: Accelerated technologies center for gene to 3d structure]] | ||
[[Category: Adrenergic]] | [[Category: Adrenergic]] | ||
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[[Category: Palmitate]] | [[Category: Palmitate]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Revision as of 14:06, 25 December 2014
Cholesterol bound form of human beta2 adrenergic receptor.
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Categories: Homo sapiens | ATCG3D, Accelerated Technologies Center for Gene to 3D Structure | Cherezov, V | Chien, E Y.T | GPCR, GPCR Network | Griffith, M T | Hanson, M A | Jaakola, V-P | Kuhn, P | Roth, C B | Stevens, R C | Velasquez, J | Accelerated technologies center for gene to 3d structure | Adrenergic | Atcg3d | Fusion | G-protein coupled receptor | Glycoprotein | Gpcr | Lipoprotein | Lysozyme | Membrane protein | Palmitate | Phosphoprotein | PSI, Protein structure initiative | Receptor | Structural genomic | Timolol | Transducer | Transmembrane
