3b8e
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3b8e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The October 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sodium-Potassium Pump'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_10 10.2210/rcsb_pdb/mom_2009_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B8E FirstGlance]. <br> | <table><tr><td colspan='2'>[[3b8e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The October 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sodium-Potassium Pump'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_10 10.2210/rcsb_pdb/mom_2009_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B8E FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MF4:TETRAFLUOROMAGNESATE(2-)'>MF4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MF4:TETRAFLUOROMAGNESATE(2-)'>MF4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b8e RCSB], [http://www.ebi.ac.uk/pdbsum/3b8e PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b8e RCSB], [http://www.ebi.ac.uk/pdbsum/3b8e PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG]] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Sodium/potassium-exchanging ATPase]] | [[Category: Sodium/potassium-exchanging ATPase]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Andersen, J P | + | [[Category: Andersen, J P]] |
| - | [[Category: Morth, J P | + | [[Category: Morth, J P]] |
| - | [[Category: Nissen, P | + | [[Category: Nissen, P]] |
| - | [[Category: Pedersen, P B | + | [[Category: Pedersen, P B]] |
| - | [[Category: Petersen, J | + | [[Category: Petersen, J]] |
| - | [[Category: Soerensen, T L.M | + | [[Category: Soerensen, T L.M]] |
| - | [[Category: Toustrup-Jensen, M S | + | [[Category: Toustrup-Jensen, M S]] |
| - | [[Category: Vilsen, B | + | [[Category: Vilsen, B]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Calcium transport]] | [[Category: Calcium transport]] | ||
Revision as of 12:13, 25 December 2014
Crystal structure of the sodium-potassium pump
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Categories: RCSB PDB Molecule of the Month | Sodium-Potassium Pump | Sodium/potassium-exchanging ATPase | Sus scrofa | Andersen, J P | Morth, J P | Nissen, P | Pedersen, P B | Petersen, J | Soerensen, T L.M | Toustrup-Jensen, M S | Vilsen, B | Atp-binding | Calcium transport | Cation pump | Glycoprotein | Hydrolase | Hydrolase-transport protein complex | Ion transport | K+-atpase | Magnesium | Membrane potential | Membrane protein | Metal-binding | Na+ | Nucleotide-binding | P-type atpase | Phosphorylation | Potassium | Potassium transport | Signal-anchor | Sodium transport | Sodium/potassium transport | Transmembrane
