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2w0d
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2w0d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0D FirstGlance]. <br> | <table><tr><td colspan='2'>[[2w0d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0D FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGS:N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE+HYDROCHLORIDE'>CGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGS:N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE+HYDROCHLORIDE'>CGS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ycm|1ycm]], [[1os9|1os9]], [[1utt|1utt]], [[1z3j|1z3j]], [[1y93|1y93]], [[1os2|1os2]], [[1jk3|1jk3]], [[1ros|1ros]], [[1utz|1utz]], [[1jiz|1jiz]], [[1rmz|1rmz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ycm|1ycm]], [[1os9|1os9]], [[1utt|1utt]], [[1z3j|1z3j]], [[1y93|1y93]], [[1os2|1os2]], [[1jk3|1jk3]], [[1ros|1ros]], [[1utz|1utz]], [[1jiz|1jiz]], [[1rmz|1rmz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w0d RCSB], [http://www.ebi.ac.uk/pdbsum/2w0d PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w0d RCSB], [http://www.ebi.ac.uk/pdbsum/2w0d PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Macrophage elastase]] | [[Category: Macrophage elastase]] | ||
| - | [[Category: Agback, T | + | [[Category: Agback, T]] |
| - | [[Category: Bertini, I | + | [[Category: Bertini, I]] |
| - | [[Category: Derbyshire, D J | + | [[Category: Derbyshire, D J]] |
| - | [[Category: Felli, I C | + | [[Category: Felli, I C]] |
| - | [[Category: Isaksson, J | + | [[Category: Isaksson, J]] |
| - | [[Category: Kovacs, H | + | [[Category: Kovacs, H]] |
| - | [[Category: Nystrom, S | + | [[Category: Nystrom, S]] |
| - | [[Category: Wallberg, H | + | [[Category: Wallberg, H]] |
[[Category: Copd]] | [[Category: Copd]] | ||
[[Category: Extracellular matrix]] | [[Category: Extracellular matrix]] | ||
Revision as of 19:19, 24 December 2014
Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.
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Categories: Homo sapiens | Macrophage elastase | Agback, T | Bertini, I | Derbyshire, D J | Felli, I C | Isaksson, J | Kovacs, H | Nystrom, S | Wallberg, H | Copd | Extracellular matrix | Glycoprotein | Hydrolase | Hydroxamate | Metal-binding | Metalloprotease | Mmp-12 | Secreted | Zymogen
