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2zlg
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zlg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZLG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2zlg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZLG FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRT:(5R,9S,12S,15S,18S,21S)-21-BENZYL-12,18-BIS(CARBOXYMETHYL)-15-CYCLOHEXYL-1-(9H-FLUOREN-9-YL)-4-METHYL-9-(2-METHYLPROPYL)-3,6,10,13,16,19-HEXAOXO-5-PHENYL-2-OXA-4,8,11,14,17,20-HEXAAZADOCOSAN-22-OIC+ACID'>MRT</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRT:(5R,9S,12S,15S,18S,21S)-21-BENZYL-12,18-BIS(CARBOXYMETHYL)-15-CYCLOHEXYL-1-(9H-FLUOREN-9-YL)-4-METHYL-9-(2-METHYLPROPYL)-3,6,10,13,16,19-HEXAOXO-5-PHENYL-2-OXA-4,8,11,14,17,20-HEXAAZADOCOSAN-22-OIC+ACID'>MRT</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zlf|2zlf]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zlf|2zlf]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zlg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zlg RCSB], [http://www.ebi.ac.uk/pdbsum/2zlg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zlg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zlg RCSB], [http://www.ebi.ac.uk/pdbsum/2zlg PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RIR1_YEAST RIR1_YEAST]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.<ref>PMID:11893751</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Ribonucleoside-diphosphate reductase]] | [[Category: Ribonucleoside-diphosphate reductase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Cooperman, B S | + | [[Category: Cooperman, B S]] |
| - | [[Category: Dealwis, C | + | [[Category: Dealwis, C]] |
| - | [[Category: Fairman, J W | + | [[Category: Fairman, J W]] |
| - | [[Category: Helmbrecht, E | + | [[Category: Helmbrecht, E]] |
| - | [[Category: Kreischer, N R | + | [[Category: Kreischer, N R]] |
| - | [[Category: LaMacchia, J | + | [[Category: LaMacchia, J]] |
| - | [[Category: Wijerathna, S R | + | [[Category: Wijerathna, S R]] |
| - | [[Category: Xu, H | + | [[Category: Xu, H]] |
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
Revision as of 18:48, 25 December 2014
The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase
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Categories: Ribonucleoside-diphosphate reductase | Saccharomyces cerevisiae | Cooperman, B S | Dealwis, C | Fairman, J W | Helmbrecht, E | Kreischer, N R | LaMacchia, J | Wijerathna, S R | Xu, H | Allosteric enzyme | Atp-binding | Dna replication | Nucleotide-binding | Oxidoreductase | Peptidomimetic inhibition eukaryotic ribonucleotide reductase | Phosphoprotein
