This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3c4h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3c4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C4H FirstGlance]. <br>
<table><tr><td colspan='2'>[[3c4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C4H FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DRL:2-METHYL-3,5,7,8-TETRAHYDRO-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE'>DRL</scene><br>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DRL:2-METHYL-3,5,7,8-TETRAHYDRO-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE'>DRL</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pa9|2pa9]], [[3c49|3c49]]</td></tr>
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pa9|2pa9]], [[3c49|3c49]]</td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARP3, ADPRT3, ADPRTL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARP3, ADPRT3, ADPRTL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c4h RCSB], [http://www.ebi.ac.uk/pdbsum/3c4h PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c4h RCSB], [http://www.ebi.ac.uk/pdbsum/3c4h PDBsum]</span></td></tr>
-
<table>
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 35: Line 37:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith, C H]]
-
[[Category: Berg, S Van den.]]
+
[[Category: Berg, S Van den]]
-
[[Category: Berglund, H.]]
+
[[Category: Berglund, H]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra, C]]
-
[[Category: Busam, R.]]
+
[[Category: Busam, R]]
-
[[Category: Collins, R.]]
+
[[Category: Collins, R]]
-
[[Category: Dahlgren, L G.]]
+
[[Category: Dahlgren, L G]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards, A M]]
-
[[Category: Flodin, S.]]
+
[[Category: Flodin, S]]
-
[[Category: Flores, A.]]
+
[[Category: Flores, A]]
-
[[Category: Graslund, S.]]
+
[[Category: Graslund, S]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Hammarstrom, M]]
-
[[Category: Herman, M D.]]
+
[[Category: Herman, M D]]
-
[[Category: Johansson, A.]]
+
[[Category: Johansson, A]]
-
[[Category: Johansson, I.]]
+
[[Category: Johansson, I]]
-
[[Category: Kallas, A.]]
+
[[Category: Kallas, A]]
-
[[Category: Karlberg, T.]]
+
[[Category: Karlberg, T]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Kotenyova, T]]
-
[[Category: Lehtio, L.]]
+
[[Category: Lehtio, L]]
-
[[Category: Moche, M.]]
+
[[Category: Moche, M]]
-
[[Category: Nilsson, M E.]]
+
[[Category: Nilsson, M E]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nordlund, P]]
-
[[Category: Nyman, T.]]
+
[[Category: Nyman, T]]
-
[[Category: Persson, C.]]
+
[[Category: Persson, C]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Structural genomic]]
-
[[Category: Sagemark, J.]]
+
[[Category: Sagemark, J]]
-
[[Category: Svensson, L.]]
+
[[Category: Svensson, L]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Thorsell, A G]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Tresaugues, L]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt, J]]
-
[[Category: Welin, M.]]
+
[[Category: Welin, M]]
[[Category: Catalytic fragment]]
[[Category: Catalytic fragment]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Enzyme-inhibitor complex]]
Line 72: Line 74:
[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Sgc]]
[[Category: Sgc]]
-
[[Category: Structural genomic]]
 
-
[[Category: Structural genomics consortium]]
 
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 13:54, 24 December 2014

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313

3c4h, resolution 2.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c4h"
Personal tools