2awt
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2awt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AWT FirstGlance]. <br> | <table><tr><td colspan='2'>[[2awt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AWT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wm2|1wm2]], [[1wm3|1wm3]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wm2|1wm2]], [[1wm3|1wm3]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB], [http://www.ebi.ac.uk/pdbsum/2awt PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB], [http://www.ebi.ac.uk/pdbsum/2awt PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[SUMO|SUMO]] | *[[SUMO|SUMO]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Chang, C F | + | [[Category: Chang, C F]] |
| - | [[Category: Chang, C K | + | [[Category: Chang, C K]] |
| - | [[Category: Chung, T L | + | [[Category: Chung, T L]] |
| - | [[Category: Huang, T H | + | [[Category: Huang, T H]] |
| - | [[Category: Li, S S.L | + | [[Category: Li, S S.L]] |
| - | [[Category: Wang, Y H | + | [[Category: Wang, Y H]] |
[[Category: Half-open barrel]] | [[Category: Half-open barrel]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Two helice]] | [[Category: Two helice]] | ||
[[Category: Ubiquitin fold]] | [[Category: Ubiquitin fold]] | ||
Revision as of 21:50, 24 December 2014
Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)
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