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| - | ==Ribosome-SecY complex. This entry 3KC4 contains 30S ribosomal subnit. The 50S ribosomal subunit can be found in PDB entry 3KCR==
| + | #REDIRECT [[4v7i]] This PDB entry is obsolete and replaced by 4v7i |
| - | <StructureSection load='3kc4' size='340' side='right' caption='[[3kc4]], [[Resolution|resolution]] 9.60Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[3kc4]] is a 21 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KC4 FirstGlance]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bo0|3bo0]], [[3bo1|3bo1]], [[3kcr|3kcr]]</td></tr>
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| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kc4 RCSB], [http://www.ebi.ac.uk/pdbsum/3kc4 PDBsum]</span></td></tr>
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| - | <table>
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| - | == Evolutionary Conservation ==
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| - | [[Image:Consurf_key_small.gif|200px|right]]
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| - | Check<jmol>
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| - | <jmolCheckbox>
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| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kc4_consurf.spt"</scriptWhenChecked>
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| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| - | <text>to colour the structure by Evolutionary Conservation</text>
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| - | </jmolCheckbox>
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| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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| - | <div style="clear:both"></div>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural data on the ribosome-channel complex are currently limited to low-resolution cryo-electron microscopy maps, including one showing a bacterial ribosome bound to a monomeric SecY complex. Using that map along with available atomic-level models of the ribosome and SecY, we have determined, through molecular dynamics flexible fitting (MDFF), an atomic-resolution model of the ribosome-channel complex. We characterized computationally the sites of ribosome-SecY interaction within the complex and determined the effect of ribosome binding on the SecY channel. We also constructed a model of a ribosome in complex with a SecY dimer by adding a second copy of SecY to the MDFF-derived model. The study involved 2.7-million-atom simulations over altogether nearly 50 ns.
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| - | Regulation of the protein-conducting channel by a bound ribosome.,Gumbart J, Trabuco LG, Schreiner E, Villa E, Schulten K Structure. 2009 Nov 11;17(11):1453-64. PMID:19913480<ref>PMID:19913480</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | ==See Also==
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| - | *[[Ribosomal protein S2|Ribosomal protein S2]]
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| - | *[[Ribosomal protein S21|Ribosomal protein S21]]
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| - | *[[Ribosomal protein S3|Ribosomal protein S3]]
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| - | *[[Ribosome 3D structures|Ribosome 3D structures]]
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Escherichia coli]]
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| - | [[Category: Escherichia coli k-12]]
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| - | [[Category: Gumbart, J C.]]
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| - | [[Category: Schreiner, E.]]
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| - | [[Category: Schulten, K.]]
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| - | [[Category: Trabuco, L G.]]
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| - | [[Category: Villa, E.]]
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| - | [[Category: Antibiotic resistance]]
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| - | [[Category: Endonuclease]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Methylation]]
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| - | [[Category: Nuclease]]
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| - | [[Category: Protein translocation]]
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| - | [[Category: Repressor]]
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| - | [[Category: Ribonucleoprotein]]
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| - | [[Category: Ribosomal protein]]
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| - | [[Category: Ribosome]]
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| - | [[Category: Ribosome-secy complex]]
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| - | [[Category: Rna-binding]]
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| - | [[Category: Rrna-binding]]
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| - | [[Category: Transcription]]
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| - | [[Category: Transcription regulation]]
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| - | [[Category: Transcription termination]]
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| - | [[Category: Translation regulation]]
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| - | [[Category: Trna-binding]]
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