3f4m

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3f4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4M FirstGlance]. <br>
<table><tr><td colspan='2'>[[3f4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F4M FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFAIP8L2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFAIP8L2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f4m RCSB], [http://www.ebi.ac.uk/pdbsum/3f4m PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f4m RCSB], [http://www.ebi.ac.uk/pdbsum/3f4m PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TP8L2_HUMAN TP8L2_HUMAN]] Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Shi, Y.]]
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[[Category: Shi, Y]]
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[[Category: Wang, J.]]
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[[Category: Wang, J]]
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[[Category: Zhang, X.]]
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[[Category: Zhang, X]]
[[Category: Immune homeostasis]]
[[Category: Immune homeostasis]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Tipe2]]
[[Category: Tipe2]]
[[Category: Tnfaip8]]
[[Category: Tnfaip8]]

Revision as of 15:26, 25 December 2014

Crystal structure of TIPE2

3f4m, resolution 1.70Å

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OCA

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