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3l2c
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3l2c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bpy 3bpy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L2C FirstGlance]. <br> | <table><tr><td colspan='2'>[[3l2c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bpy 3bpy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L2C FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFX, AFX1, FOXO4, MLLT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFX, AFX1, FOXO4, MLLT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l2c RCSB], [http://www.ebi.ac.uk/pdbsum/3l2c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l2c RCSB], [http://www.ebi.ac.uk/pdbsum/3l2c PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN]] A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein. | [[http://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN]] A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Boura, E | + | [[Category: Boura, E]] |
| - | [[Category: Brynda, J | + | [[Category: Brynda, J]] |
| - | [[Category: Obsil, T | + | [[Category: Obsil, T]] |
| - | [[Category: Obsilova, V | + | [[Category: Obsilova, V]] |
| - | [[Category: Silhan, J | + | [[Category: Silhan, J]] |
| - | [[Category: Sulc, M | + | [[Category: Sulc, M]] |
[[Category: Forkhead]] | [[Category: Forkhead]] | ||
[[Category: Forkhead box]] | [[Category: Forkhead box]] | ||
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
[[Category: Winged helix]] | [[Category: Winged helix]] | ||
Revision as of 11:14, 20 January 2015
Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA
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