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3hha

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hha]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hha]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOW:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2Z)-2-IMINOETHYL]-3-METHYL-L-PHENYLALANINAMIDE'>NOW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOW:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2Z)-2-IMINOETHYL]-3-METHYL-L-PHENYLALANINAMIDE'>NOW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL1, CTSL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL1, CTSL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hha RCSB], [http://www.ebi.ac.uk/pdbsum/3hha PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hha RCSB], [http://www.ebi.ac.uk/pdbsum/3hha PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Cathepsin L]]
[[Category: Cathepsin L]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Asaad, N.]]
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[[Category: Asaad, N]]
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[[Category: Augustin, M.]]
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[[Category: Augustin, M]]
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[[Category: Bethel, P A.]]
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[[Category: Bethel, P A]]
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[[Category: Coulson, M D.]]
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[[Category: Coulson, M D]]
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[[Category: Dawson, J.]]
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[[Category: Dawson, J]]
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[[Category: Ford, S J.]]
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[[Category: Ford, S J]]
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[[Category: Gerhardt, S.]]
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[[Category: Gerhardt, S]]
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[[Category: Grist, M.]]
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[[Category: Grist, M]]
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[[Category: Hamlin, G A.]]
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[[Category: Hamlin, G A]]
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[[Category: James, M J.]]
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[[Category: James, M J]]
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[[Category: Jones, E V.]]
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[[Category: Jones, E V]]
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[[Category: Karoutchi, G I.]]
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[[Category: Karoutchi, G I]]
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[[Category: Kenny, P W.]]
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[[Category: Kenny, P W]]
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[[Category: Krapp, S.]]
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[[Category: Krapp, S]]
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[[Category: Morley, A D.]]
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[[Category: Morley, A D]]
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[[Category: Oldham, K.]]
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[[Category: Oldham, K]]
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[[Category: Rankine, N.]]
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[[Category: Rankine, N]]
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[[Category: Ryan, D.]]
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[[Category: Ryan, D]]
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[[Category: Simader, H.]]
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[[Category: Simader, H]]
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[[Category: Steinbacher, S.]]
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[[Category: Steinbacher, S]]
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[[Category: Wells, S L.]]
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[[Category: Wells, S L]]
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[[Category: Wood, L.]]
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[[Category: Wood, L]]
[[Category: Cathepsin l]]
[[Category: Cathepsin l]]
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]

Revision as of 12:51, 25 December 2014

Crystal structure of cathepsin L in complex with AZ12878478

3hha, resolution 1.27Å

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