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3fmr

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fmr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3d0d 3d0d]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMR FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fmr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3d0d 3d0d]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TN4:(1R,2S,3S,4R)-4-HYDROXY-2-METHOXY-4-METHYL-3-[(2R,3R)-2-METHYL-3-(3-METHYLBUT-2-EN-1-YL)OXIRAN-2-YL]CYCLOHEXYL+(CHLOROACETYL)CARBAMATE'>TN4</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TN4:(1R,2S,3S,4R)-4-HYDROXY-2-METHOXY-4-METHYL-3-[(2R,3R)-2-METHYL-3-(3-METHYLBUT-2-EN-1-YL)OXIRAN-2-YL]CYCLOHEXYL+(CHLOROACETYL)CARBAMATE'>TN4</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fm3|3fm3]], [[3fmq|3fmq]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fm3|3fm3]], [[3fmq|3fmq]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECU10_0750, MAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECU10_0750, MAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fmr RCSB], [http://www.ebi.ac.uk/pdbsum/3fmr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fmr RCSB], [http://www.ebi.ac.uk/pdbsum/3fmr PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Encephalitozoon cuniculi]]
[[Category: Encephalitozoon cuniculi]]
[[Category: Methionyl aminopeptidase]]
[[Category: Methionyl aminopeptidase]]
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[[Category: Adams, J.]]
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[[Category: Adams, J]]
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[[Category: Almo, S C.]]
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[[Category: Almo, S C]]
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[[Category: Alvarado, J J.]]
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[[Category: Alvarado, J J]]
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[[Category: Burley, S K.]]
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[[Category: Burley, S K]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Structural genomic]]
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[[Category: Russell, M.]]
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[[Category: Russell, M]]
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[[Category: Toro, R.]]
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[[Category: Toro, R]]
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[[Category: Weiss, L M.]]
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[[Category: Weiss, L M]]
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[[Category: Zhang, A.]]
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[[Category: Zhang, A]]
[[Category: Aminopeptidase]]
[[Category: Aminopeptidase]]
[[Category: Cobalt]]
[[Category: Cobalt]]
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[[Category: Encephalitozoon cuniculi]]
 
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Metal-binding]]
[[Category: Metal-binding]]
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[[Category: Metap2 tnp470 complex]]
[[Category: Metap2 tnp470 complex]]
[[Category: Methionine aminopeptidase type2]]
[[Category: Methionine aminopeptidase type2]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Nysgxrc]]
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[[Category: Protease]]
[[Category: Protease]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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Revision as of 13:50, 6 November 2014

Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor TNP470 bound

3fmr, resolution 2.89Å

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