1d5v
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1d5v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D5V FirstGlance]. <br> | <table><tr><td colspan='2'>[[1d5v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D5V FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d5v RCSB], [http://www.ebi.ac.uk/pdbsum/1d5v PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d5v RCSB], [http://www.ebi.ac.uk/pdbsum/1d5v PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/FOXC2_HUMAN FOXC2_HUMAN]] Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:[http://omim.org/entry/153200 153200]]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment.<ref>PMID:11078474</ref> Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:[http://omim.org/entry/153300 153300]]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:[http://omim.org/entry/153400 153400]]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).<ref>PMID:11499682</ref> | [[http://www.uniprot.org/uniprot/FOXC2_HUMAN FOXC2_HUMAN]] Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:[http://omim.org/entry/153200 153200]]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment.<ref>PMID:11078474</ref> Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:[http://omim.org/entry/153300 153300]]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:[http://omim.org/entry/153400 153400]]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).<ref>PMID:11499682</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Carlsson, P | + | [[Category: Carlsson, P]] |
| - | [[Category: Cederberg, A | + | [[Category: Cederberg, A]] |
| - | [[Category: Dongen, M J.P van | + | [[Category: Dongen, M J.P van]] |
| - | [[Category: Enerback, S | + | [[Category: Enerback, S]] |
| - | [[Category: Wikstrom, M | + | [[Category: Wikstrom, M]] |
[[Category: Dna-recognition helix]] | [[Category: Dna-recognition helix]] | ||
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
[[Category: Winged helix]] | [[Category: Winged helix]] | ||
Revision as of 18:17, 22 December 2014
SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)
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