1rj2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1rj2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RJ2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1rj2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RJ2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kz7|1kz7]], [[1kzg|1kzg]], [[1lb1|1lb1]], [[1foe|1foe]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kz7|1kz7]], [[1kzg|1kzg]], [[1lb1|1lb1]], [[1foe|1foe]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCF2L, OST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCF2L, OST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rj2 RCSB], [http://www.ebi.ac.uk/pdbsum/1rj2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rj2 RCSB], [http://www.ebi.ac.uk/pdbsum/1rj2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCF2L_RAT MCF2L_RAT]] Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Rossman, K L | + | [[Category: Rossman, K L]] |
| - | [[Category: Sondek, J | + | [[Category: Sondek, J]] |
| - | [[Category: Worthylake, D K | + | [[Category: Worthylake, D K]] |
[[Category: Dbl homology]] | [[Category: Dbl homology]] | ||
[[Category: Guanine nucleotide exchange factor]] | [[Category: Guanine nucleotide exchange factor]] | ||
Revision as of 11:16, 25 December 2014
Crystal structure of the DH/PH fragment of Dbs without bound GTPase
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