1s4z
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s4z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[1s4z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4Z FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX1, CBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CHAF1A, CAIP150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX1, CBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CHAF1A, CAIP150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s4z RCSB], [http://www.ebi.ac.uk/pdbsum/1s4z PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s4z RCSB], [http://www.ebi.ac.uk/pdbsum/1s4z PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CBX1_HUMAN CBX1_HUMAN]] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. [[http://www.uniprot.org/uniprot/CAF1A_MOUSE CAF1A_MOUSE]] Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Hirshberg, M | + | [[Category: Hirshberg, M]] |
| - | [[Category: Laue, E D | + | [[Category: Laue, E D]] |
| - | [[Category: Lyon, D | + | [[Category: Lyon, D]] |
| - | [[Category: Mott, H R | + | [[Category: Mott, H R]] |
| - | [[Category: Murzina, N V | + | [[Category: Murzina, N V]] |
| - | [[Category: Nielsen, P R | + | [[Category: Nielsen, P R]] |
| - | [[Category: Nietlispach, D | + | [[Category: Nietlispach, D]] |
| - | [[Category: Okuwaki, M | + | [[Category: Okuwaki, M]] |
| - | [[Category: Thiru, A | + | [[Category: Thiru, A]] |
| - | [[Category: Verreault, A | + | [[Category: Verreault, A]] |
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
Revision as of 07:07, 24 December 2014
HP1 chromo shadow domain in complex with PXVXL motif of CAF-1
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