1gfh
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1gfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GFH FirstGlance]. <br> | <table><tr><td colspan='2'>[[1gfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GFH FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gay|1gay]], [[1gf8|1gf8]], [[1gf9|1gf9]], [[1gfa|1gfa]], [[1gfe|1gfe]], [[1gfg|1gfg]], [[1gfj|1gfj]], [[1gfk|1gfk]], [[1gfr|1gfr]], [[1gft|1gft]], [[1gfu|1gfu]], [[1gfv|1gfv]], [[1inu|1inu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gay|1gay]], [[1gf8|1gf8]], [[1gf9|1gf9]], [[1gfa|1gfa]], [[1gfe|1gfe]], [[1gfg|1gfg]], [[1gfj|1gfj]], [[1gfk|1gfk]], [[1gfr|1gfr]], [[1gft|1gft]], [[1gfu|1gfu]], [[1gfv|1gfv]], [[1inu|1inu]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gfh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gfh RCSB], [http://www.ebi.ac.uk/pdbsum/1gfh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gfh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gfh RCSB], [http://www.ebi.ac.uk/pdbsum/1gfh PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[http://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref> | [[http://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[http://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
| - | [[Category: Funahashi, J | + | [[Category: Funahashi, J]] |
| - | [[Category: Takano, K | + | [[Category: Takano, K]] |
| - | [[Category: Yamagata, Y | + | [[Category: Yamagata, Y]] |
| - | [[Category: Yutani, K | + | [[Category: Yutani, K]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrophilic]] | [[Category: Hydrophilic]] | ||
[[Category: Stability]] | [[Category: Stability]] | ||
[[Category: Surface]] | [[Category: Surface]] | ||
Revision as of 19:00, 22 December 2014
CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
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Categories: Homo sapiens | Lysozyme | Funahashi, J | Takano, K | Yamagata, Y | Yutani, K | Hydrolase | Hydrophilic | Stability | Surface
