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1kke
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kke]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_dearing Mammalian orthoreovirus 3 dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKE FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kke]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_dearing Mammalian orthoreovirus 3 dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKE FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kke RCSB], [http://www.ebi.ac.uk/pdbsum/1kke PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kke RCSB], [http://www.ebi.ac.uk/pdbsum/1kke PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mammalian orthoreovirus 3 dearing]] | [[Category: Mammalian orthoreovirus 3 dearing]] | ||
| - | [[Category: Chappell, J D | + | [[Category: Chappell, J D]] |
| - | [[Category: Dermody, T S | + | [[Category: Dermody, T S]] |
| - | [[Category: Prota, A E | + | [[Category: Prota, A E]] |
| - | [[Category: Stehle, T | + | [[Category: Stehle, T]] |
[[Category: Beta-barrel]] | [[Category: Beta-barrel]] | ||
[[Category: Beta-spiral]] | [[Category: Beta-spiral]] | ||
Revision as of 03:22, 25 December 2014
Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer
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