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1m2z
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M2Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M2Z FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m2z RCSB], [http://www.ebi.ac.uk/pdbsum/1m2z PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m2z RCSB], [http://www.ebi.ac.uk/pdbsum/1m2z PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | [[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Apolito, C J | + | [[Category: Apolito, C J]] |
| - | [[Category: Bledsoe, R B | + | [[Category: Bledsoe, R B]] |
| - | [[Category: Consler, T G | + | [[Category: Consler, T G]] |
| - | [[Category: Delves, C J | + | [[Category: Delves, C J]] |
| - | [[Category: Lambert, M H | + | [[Category: Lambert, M H]] |
| - | [[Category: Mckee, D D | + | [[Category: Mckee, D D]] |
| - | [[Category: Montana, V G | + | [[Category: Montana, V G]] |
| - | [[Category: Moore, J T | + | [[Category: Moore, J T]] |
| - | [[Category: Parks, D J | + | [[Category: Parks, D J]] |
| - | [[Category: Pearce, K H | + | [[Category: Pearce, K H]] |
| - | [[Category: Stanley, T B | + | [[Category: Stanley, T B]] |
| - | [[Category: Stewart, E L | + | [[Category: Stewart, E L]] |
| - | [[Category: Willson, T M | + | [[Category: Willson, T M]] |
| - | [[Category: Xu, H E | + | [[Category: Xu, H E]] |
[[Category: Charge clamp]] | [[Category: Charge clamp]] | ||
[[Category: Coactivator]] | [[Category: Coactivator]] | ||
Revision as of 16:42, 5 January 2015
Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif
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Categories: Homo sapiens | Apolito, C J | Bledsoe, R B | Consler, T G | Delves, C J | Lambert, M H | Mckee, D D | Montana, V G | Moore, J T | Parks, D J | Pearce, K H | Stanley, T B | Stewart, E L | Willson, T M | Xu, H E | Charge clamp | Coactivator | Dexamethasone | Dimer interface | Glucocorticoid receptor | Hormone binding pocket | Hormone-hormone activator complex | Tif2
